Interaction between MBMATCs and the immune microenvironment.

Interaction between MBMATCs and the immune microenvironment.

<p>(A) Scatter plot depicting the outgoing and incoming interaction strength for each cell subpopulation within PTs, ECMs and MBMs. (B) Dot plot showing ligand-receptor interactions from specified subpopulations (Mela3, CD8-LEF1, CD8-NKG7, CD8-HIF1A) to the CD8-HAVCR2 subpopulation across PTs,...

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Bibliografski detalji
Glavni autor: Jingxin Zeng (18773484) (author)
Daljnji autori: Ling Lin (57361) (author), Yangyang Ma (6329852) (author), Wenzhe Huang (446343) (author), Quan Luo (1423180) (author), Ju Wen (14784239) (author)
Izdano: 2025
Teme:
Cell Biology
Genetics
Neuroscience
Biotechnology
Immunology
Developmental Biology
Cancer
Hematology
Virology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
limited treatment efficacy
associated tumor cells
adhesion genes (<
nucleus rna sequencing
metastatic tumor subpopulation
26 melanoma samples
study identifies mbmatcs
mbm ecosystems showed
div >< p
melanoma brain metastasis
metastatic pathways
bulk rna
brain metastasis
melanoma patients
validation cohorts
upregulated neural
treg enrichment
remains lethal
potential activity
nrg3 </
ncam1 </
mela3 ).
lag3 </
high risk
havcr2 </
early stratification
clinical relevance
cellular origins
cellular origin
brain tropism
>), suggesting
1 </
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Sažetak:<p>(A) Scatter plot depicting the outgoing and incoming interaction strength for each cell subpopulation within PTs, ECMs and MBMs. (B) Dot plot showing ligand-receptor interactions from specified subpopulations (Mela3, CD8-LEF1, CD8-NKG7, CD8-HIF1A) to the CD8-HAVCR2 subpopulation across PTs, ECMs, and MBMs. Dot size corresponds to the statistical significance (P-value), and color intensity represents the interaction strength.</p> <p>(TIF)</p>

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