Interaction between MBMATCs and the immune microenvironment.
<p>(A) Scatter plot depicting the outgoing and incoming interaction strength for each cell subpopulation within PTs, ECMs and MBMs. (B) Dot plot showing ligand-receptor interactions from specified subpopulations (Mela3, CD8-LEF1, CD8-NKG7, CD8-HIF1A) to the CD8-HAVCR2 subpopulation across PTs,...
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2025
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| _version_ | 1849927642844758016 |
|---|---|
| author | Jingxin Zeng (18773484) |
| author2 | Ling Lin (57361) Yangyang Ma (6329852) Wenzhe Huang (446343) Quan Luo (1423180) Ju Wen (14784239) |
| author2_role | author author author author author |
| author_facet | Jingxin Zeng (18773484) Ling Lin (57361) Yangyang Ma (6329852) Wenzhe Huang (446343) Quan Luo (1423180) Ju Wen (14784239) |
| author_role | author |
| dc.creator.none.fl_str_mv | Jingxin Zeng (18773484) Ling Lin (57361) Yangyang Ma (6329852) Wenzhe Huang (446343) Quan Luo (1423180) Ju Wen (14784239) |
| dc.date.none.fl_str_mv | 2025-11-24T18:27:42Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0336502.s004 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Interaction_between_MBMATCs_and_the_immune_microenvironment_/30696978 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </ |
| dc.title.none.fl_str_mv | Interaction between MBMATCs and the immune microenvironment. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>(A) Scatter plot depicting the outgoing and incoming interaction strength for each cell subpopulation within PTs, ECMs and MBMs. (B) Dot plot showing ligand-receptor interactions from specified subpopulations (Mela3, CD8-LEF1, CD8-NKG7, CD8-HIF1A) to the CD8-HAVCR2 subpopulation across PTs, ECMs, and MBMs. Dot size corresponds to the statistical significance (P-value), and color intensity represents the interaction strength.</p> <p>(TIF)</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_53d14259dd5ca4fac15048a95cd2fe6a |
| identifier_str_mv | 10.1371/journal.pone.0336502.s004 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30696978 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Interaction between MBMATCs and the immune microenvironment.Jingxin Zeng (18773484)Ling Lin (57361)Yangyang Ma (6329852)Wenzhe Huang (446343)Quan Luo (1423180)Ju Wen (14784239)Cell BiologyGeneticsNeuroscienceBiotechnologyImmunologyDevelopmental BiologyCancerHematologyVirologyBiological Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedlimited treatment efficacyassociated tumor cellsadhesion genes (<nucleus rna sequencingmetastatic tumor subpopulation26 melanoma samplesstudy identifies mbmatcsmbm ecosystems showeddiv >< pmelanoma brain metastasismetastatic pathwaysbulk rnabrain metastasismelanoma patientsvalidation cohortsupregulated neuraltreg enrichmentremains lethalpotential activitynrg3 </ncam1 </mela3 ).lag3 </high riskhavcr2 </early stratificationclinical relevancecellular originscellular originbrain tropism>), suggesting1 </<p>(A) Scatter plot depicting the outgoing and incoming interaction strength for each cell subpopulation within PTs, ECMs and MBMs. (B) Dot plot showing ligand-receptor interactions from specified subpopulations (Mela3, CD8-LEF1, CD8-NKG7, CD8-HIF1A) to the CD8-HAVCR2 subpopulation across PTs, ECMs, and MBMs. Dot size corresponds to the statistical significance (P-value), and color intensity represents the interaction strength.</p> <p>(TIF)</p>2025-11-24T18:27:42ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0336502.s004https://figshare.com/articles/figure/Interaction_between_MBMATCs_and_the_immune_microenvironment_/30696978CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306969782025-11-24T18:27:42Z |
| spellingShingle | Interaction between MBMATCs and the immune microenvironment. Jingxin Zeng (18773484) Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </ |
| status_str | publishedVersion |
| title | Interaction between MBMATCs and the immune microenvironment. |
| title_full | Interaction between MBMATCs and the immune microenvironment. |
| title_fullStr | Interaction between MBMATCs and the immune microenvironment. |
| title_full_unstemmed | Interaction between MBMATCs and the immune microenvironment. |
| title_short | Interaction between MBMATCs and the immune microenvironment. |
| title_sort | Interaction between MBMATCs and the immune microenvironment. |
| topic | Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </ |