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<div><p>Phosphoglycerate mutase/protein phosphatase (PGAM5)-mediated cell death plays an important role in multiple liver diseases. However, few studies have confirmed the regulatory mechanism of melatonin acting on PGAM5-mediated cell death in the context of liver ischemia-reperfusion (...

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Bibliographic Details
Main Author: Xiaoyi Shi (3825754) (author)
Other Authors: Jiakai Zhang (3825760) (author), Jie Gao (10266) (author), Danfeng Guo (6380450) (author), Shuijun Zhang (294875) (author), Xu Chen (432759) (author), Hongwei Tang (129296) (author)
Published: 2024
Subjects:
Biochemistry
Microbiology
Cell Biology
Molecular Biology
Neuroscience
Physiology
Immunology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
oxidative stress index
mediated hepatocyte protection
multiple liver diseases
mediated liver protection
mediated cell death
melatonin supplementation blocked
induced liver injury
pgam5 protein expression
r injury model
liver injury
reoxygenation model
protein phosphatase
liver ischemia
cell hypoxia
cell apoptosis
cell activity
r injury
survival advantage
silencing pgam5
significantly elevated
results indicated
results achieved
protective advantage
predominantly localized
pgam5 silencing
new paradigm
necrosis area
melatonin pretreatment
melatonin acting
data indicated
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