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<div><p>Phosphoglycerate mutase/protein phosphatase (PGAM5)-mediated cell death plays an important role in multiple liver diseases. However, few studies have confirmed the regulatory mechanism of melatonin acting on PGAM5-mediated cell death in the context of liver ischemia-reperfusion (...

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Bibliographic Details
Main Author:	Xiaoyi Shi (3825754) (author)
Other Authors:	Jiakai Zhang (3825760) (author), Jie Gao (10266) (author), Danfeng Guo (6380450) (author), Shuijun Zhang (294875) (author), Xu Chen (432759) (author), Hongwei Tang (129296) (author)
Published:	2024
Subjects:	Biochemistry Microbiology Cell Biology Molecular Biology Neuroscience Physiology Immunology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified oxidative stress index mediated hepatocyte protection multiple liver diseases mediated liver protection mediated cell death melatonin supplementation blocked induced liver injury pgam5 protein expression r injury model liver injury reoxygenation model protein phosphatase liver ischemia cell hypoxia cell apoptosis cell activity r injury survival advantage silencing pgam5 significantly elevated results indicated results achieved protective advantage predominantly localized pgam5 silencing new paradigm necrosis area melatonin pretreatment melatonin acting data indicated
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