Low iron in the cytoplasm in LD-R-infected-MФs promotes p62/SQSTM1 mediated non-canonically activation of NRF2 (A.i.a.)

<p>Western blot of whole cell lysate showing the expression of p62 in uninfected-MФs, LD-S, LD-R infected-MФs at 4 hrs pi and DFO-treated MФs keeping β-actin as the loading control. <b>(A.i.b.)</b> Relative intensity of p62 with respect to β-actin showed a significant upregulation...

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Main Author:	Souradeepa Ghosh (14276657) (author)
Other Authors:	Krishna Vamshi Chigicherla (20649145) (author), Shirin Dasgupta (20649148) (author), Yasuyuki Goto (22965) (author), Budhaditya Mukherjee (106862) (author)
Published:	2025
Subjects:	Biochemistry Medicine Microbiology Cell Biology Biotechnology Evolutionary Biology Ecology Inorganic Chemistry Hematology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified unresponsiveness points towards treating visceral leishmaniasis sustaining heightened levels selectively reshuffling macrophage recent clinical isolates leishmania donovani </ inherent metabolic shift even though anti div >< p surface iron exporter subsequent iron insufficiency higher iron utilization triggering oxidative outburst gained increased potential withstand elevated ros elevated ros levels pv thereby gaining pentavalent antimonials relies surplus iron iron within oxidative stress increased erythrophagocytosis two proteases survival edge surprising strategy study highlights sensitive counterparts parasitophorous vacuoles leishmanial activity intracellular pathogens infected macrophages genetic adaptation evolutionary persistence complex interplay cd47 surveillance aggressive proliferation
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Low iron in the cytoplasm in LD-R-infected-MФs promotes p62/SQSTM1 mediated non-canonically activation of NRF2 (A.i.a.)

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