Diagram showing pleiotropy of loci affecting drug-resistance phenotypes.

An arrow pulling on an allele or genotype indicates that that drug selects for that allele or copy-number variant. For example, amodiaquine selects for alleles 86Y and Y184 in the pfmdr1 gene and allele 76T in the pfcrt gene. Thicker arrows indicate str...

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Bibliographic Details
Main Author:	Robert J. Zupko (12035446) (author)
Other Authors:	Tran Dang Nguyen (12035449) (author), Anyirékun Fabrice Somé (12035452) (author), Thu Nguyen-Anh Tran (12035455) (author), Jaline Gerardin (845738) (author), Patrick Dudas (12035458) (author), Dang Duy Hoang Giang (12035461) (author), Kien Trung Tran (12035464) (author), Amy Wesolowski (105098) (author), Jean-Bosco Ouédraogo (3159024) (author), Maciej F. Boni (10297456) (author)
Published:	2022
Subjects:	Medicine Pharmacology Biotechnology Cancer Science Policy Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified model year 2038 high impact ’ based stochastic model added spatial structure 2038 ), due de novo </ term drug resistance rebalanced mft approach local malaria response may accelerate near increased act use using al alone treatment failure rates div >< p 580y frequency ranging plasmodium falciparum </ artemisinin combination therapies approximately equal long scenarios incorporating mft hbhi malaria setting acts may affect falciparum </ treatment failures line therapies equal deployment early failure pfkelch13 </ p </ term outcomes term effects may occur increased rate increased emphasis increased adoption validated individual status quo resistant genotypes recommended first particularly germane multiple first market drugs improving guidance burkina faso
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Diagram showing pleiotropy of loci affecting drug-resistance phenotypes.

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