Chlamydia trachomatis triggers host cell ferroptosis through SLC7A11 downregulation and consequent glutathione depletion.

(A) Immunoblot analysis of multiple ferroptosis-associated proteins and chlamydial HSP60 was performed in cells infected with various MOIs of Chlamydia trachomatis serovar D (CT-D) at 72 h.p.i., compared to mock-infected cells. (B) Immunoblot analysis of SLC7A11, GPx4, GA...

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Bibliographic Details
Main Author:	Wentao Chen (626428) (author)
Other Authors:	Xin Su (338394) (author), Yuying Pan (14800243) (author), Han Zhou (109068) (author), Yidan Gao (14620035) (author), Xuemei Wang (39992) (author), Lijuan Jiang (501223) (author), Lihong Zeng (15594179) (author), Qingqing Xu (465549) (author), Xueying Yu (605947) (author), Xiaona Yin (9023591) (author), Zhanqin Feng (3721183) (author), Bao Zhang (186933) (author), Wei Zhao (14321) (author), Yaohua Xue (3150252) (author), Lingli Tang (436791) (author), Heping Zheng (538162) (author)
Published:	2025
Subjects:	Biophysics Microbiology Cell Biology Immunology Cancer Infectious Diseases Computational Biology Biological Sciences not elsewhere classified vitamin e reduces trends toward attenuation prevalent bacterial agent low genital tract like activity factor host protein slc7a11 host cells plays deficient strain fails conserved survival strategies sexually transmitted infections chlamydia trachomatis ,</ cpaf ), resulting new infections chlamydia </ significant threat reproductive health process involves orchestrated lysis novel mechanism lipid peroxidation inhibiting ferroptosis induce ferroptosis glutathione depletion crucial role chlamydial protease
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<i>Chlamydia trachomatis</i> triggers host cell ferroptosis through SLC7A11 downregulation and consequent glutathione depletion.

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