Targeted screen of 20 conserved neuronal RBPs reveals eight novel associative memory regulators.

Targeted screen of 20 conserved neuronal RBPs reveals eight novel associative memory regulators.

<p>(<b>A</b>) Short-term and intermediate-term associative memory (STM and ITM) assay workflow using adult-only RNAi knockdown. Worms that are neuronally sensitive to RNAi, LC108<i>(usIS69[myo-2p</i>::<i>mCherry + unc119p</i>::<i>sid-1])</i>, wer...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Ashley N. Hayden (19871128) (author)
مؤلفون آخرون: Katie L. Brandel (19871131) (author), Edward W. Pietryk (5777888) (author), Paul R. Merlau (19871134) (author), Priyadharshini Vijayakumar (19871137) (author), Emily J. Leptich (19871140) (author), Elizabeth S. Gaytan (19871143) (author), Meredith I. Williams (19871146) (author), Connie W. Ni (19871149) (author), Hsiao-Tuan Chao (4454008) (author), Jill A. Rosenfeld (9606199) (author), Rachel N. Arey (19871152) (author)
منشور في: 2024
الموضوعات:
Biochemistry
Neuroscience
Pharmacology
Evolutionary Biology
Immunology
Cancer
Mental Health
Infectious Diseases
Biological Sciences not elsewhere classified
test evolutionary conservation
single nucleotide variants
potential new source
behavioral screening reveals
potential functional significance
leveraging human datasets
></ u ><
reveal memory regulators
div >< p
x </ u
b </ u
identifies ybx dysfunction
binding protein required
20 conserved rbps
u ><
unknown significance
rbp dysfunction
human genome
conserved residue
binding proteins
ybxs </
ybx3 </
legans </
elegans </
e </
c </
3 </
study highlights
regulate translation
rbp family
promote memory
neurological symptoms
neurological phenotypes
neurological disorders
nervous system
memory ability
key symptom
functionally replace
cognitive impairments
closest ortholog
associative learning
000 rbps
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