Putative PPT1 substrates are enriched at the synapse and display persistent palmitoylation.

Putative PPT1 substrates are enriched at the synapse and display persistent palmitoylation.

<p><b>(A)</b> Venn diagram of 3 palmitome experiments exhibits 1,379 common proteins. <b>(B)</b> Volcano plot indicates 242 proteins are significantly differentially palmitoylated (4 decrease; 238 increase; 1.5-fold, <i>p</i> < 0.05; blue lines; <b>...

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Bibliographic Details
Main Author:	Erica L. Gorenberg (12329728) (author)
Other Authors:	Sofia Massaro Tieze (12329731) (author), Betül Yücel (12329734) (author), Helen R. Zhao (12329737) (author), Vicky Chou (12329740) (author), Gregory S. Wirak (12329743) (author), Susumu Tomita (6956876) (author), TuKiet T. Lam (610361) (author), Sreeganga S. Chandra (12329746) (author)
Published:	2022
Subjects:	Biophysics Biochemistry Genetics Molecular Biology Neuroscience Biotechnology Biological Sciences not elsewhere classified synaptic adhesion molecules utilized acyl resin implicate molecular pathways disulfide bond formation validated putative substrates mediating synapse functions div >< p devastating neurodegenerative disease cysteine depalmitoylation sites neurodegenerative diseases molecular dissection disulfide bonds disease mechanisms acyl rac vivo </ therapeutic development resource identifying ptms ). mouse brains mitochondrial proteins mature protein mass spectrometry largely undescribed including channels identify proteins highlights roles function mutations exocytic components direct depalmitoylation depalmitoylation plays data highlight basic understanding assisted capture
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