Wnt/β-catenin signaling hyperactivation delays primary cilia formation in RPE1, NIH3T3, and IMCD3 cells.

(A) Images of RPE1 cells expressing the 7xTGC Wnt reporter construct treated with Wnt3a-CM for the indicated time points. The increase in GFP signal reflects Wnt activation. (B) Western blot analysis of saponin lysed RPE1 cells treated with Co-CM or Wnt...

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Bibliographic Details
Main Author:	Cheng Yuan (160315) (author)
Other Authors:	Annett Neuner (222233) (author), Johanna Streubel (22170461) (author), Ayushi Bhanushali (22170464) (author), Matias Simons (152669) (author), Sergio P. Acebrón (22170467) (author), Gislene Pereira (382411) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Neuroscience Biotechnology Developmental Biology Cancer various cellular functions particularly signal transduction elevated ofd1 levels data also indicate based organelle essential elevated wnt activity cilia membrane establishment regulating signaling pathways signaling pathways lrp6 signaling xlink "> wnt signals vesicle docking remove cp110 reduced rab8 primary cilium mother centrioles findings show extensively studied critical modulators critical events centriolar satellites cell fate axoneme extension
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Wnt/β-catenin signaling hyperactivation delays primary cilia formation in RPE1, NIH3T3, and IMCD3 cells.

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