Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations.
<p><b>A)</b> Example of grating stimuli separated by 15° for difficult task (top), schematic of optogenetic manipulations activating only PV cells expressing ChR2 (middle), optogenetic stimulation timings for all four conditions aligned to stimulus onset (STIM ON) or offset (STIM O...
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2025
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| Sumario: | <p><b>A)</b> Example of grating stimuli separated by 15° for difficult task (top), schematic of optogenetic manipulations activating only PV cells expressing ChR2 (middle), optogenetic stimulation timings for all four conditions aligned to stimulus onset (STIM ON) or offset (STIM OFF) (bottom). <b>B)</b> Normalized average discrimination performance, <i>d’</i>, <b>C)</b> normalized average rate of correct ‘go’ trials (hit rate), and <b>D)</b> normalized average rate of incorrect ‘no-go’ trials (false alarm rate), as a function of laser power for ‘entire’ window (black, <i>N</i> = 7, 24 sessions) and ‘early’ window (red, <i>N</i> = 8, 28 sessions) conditions. Data is normalized by subtracting the value of the 0 power level (see Methods). <b>E–G)</b> same as in B–D) but for ‘late1’ window (blue, <i>N</i> = 7, 25 sessions) and ‘late2’ window (green, <i>N</i> = 7, 25 sessions) conditions. All plots: shaded line is the 95th percentile of data shuffled 1,000 times, using bootstrapping with replacement. Horizontal bars with corresponding colors indicate significant deviation (<i>p</i> < 0.05) from no laser stimulation. See also <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003518#pbio.3003518.s007" target="_blank">S7 Fig</a>.</p> |
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