Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations.
<p><b>A)</b> Example of grating stimuli separated by 15° for difficult task (top), schematic of optogenetic manipulations activating only PV cells expressing ChR2 (middle), optogenetic stimulation timings for all four conditions aligned to stimulus onset (STIM ON) or offset (STIM O...
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2025
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| _version_ | 1849927627023843328 |
|---|---|
| author | Lilia Kukovska (22683586) |
| author2 | Katharina A. Wilmes (22683589) Natsumi Y. Homma (22683592) Claudia Clopath (324706) Jasper Poort (22683595) |
| author2_role | author author author author |
| author_facet | Lilia Kukovska (22683586) Katharina A. Wilmes (22683589) Natsumi Y. Homma (22683592) Claudia Clopath (324706) Jasper Poort (22683595) |
| author_role | author |
| dc.creator.none.fl_str_mv | Lilia Kukovska (22683586) Katharina A. Wilmes (22683589) Natsumi Y. Homma (22683592) Claudia Clopath (324706) Jasper Poort (22683595) |
| dc.date.none.fl_str_mv | 2025-11-25T18:37:26Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pbio.3003518.g003 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Stimulating_PV_cells_at_nonsilencing_levels_does_not_improve_performance_of_difficult_visual_discriminations_/30714565 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Neuroscience Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified xlink "> inhibition three major factors strong competitive interactions photon imaging showed balanced cortical activity primary visual cortex sustained v1 activity combined optogenetic activation v1 cells captured moderate pv activation moderate activation visual discriminations expressing cells nonlinear activation dependent activation activation strength task difficulty stimulus onset perceptual discrimination difficult discriminations delineates conditions circuit model behavioral effects |
| dc.title.none.fl_str_mv | Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><b>A)</b> Example of grating stimuli separated by 15° for difficult task (top), schematic of optogenetic manipulations activating only PV cells expressing ChR2 (middle), optogenetic stimulation timings for all four conditions aligned to stimulus onset (STIM ON) or offset (STIM OFF) (bottom). <b>B)</b> Normalized average discrimination performance, <i>d’</i>, <b>C)</b> normalized average rate of correct ‘go’ trials (hit rate), and <b>D)</b> normalized average rate of incorrect ‘no-go’ trials (false alarm rate), as a function of laser power for ‘entire’ window (black, <i>N</i> = 7, 24 sessions) and ‘early’ window (red, <i>N</i> = 8, 28 sessions) conditions. Data is normalized by subtracting the value of the 0 power level (see Methods). <b>E–G)</b> same as in B–D) but for ‘late1’ window (blue, <i>N</i> = 7, 25 sessions) and ‘late2’ window (green, <i>N</i> = 7, 25 sessions) conditions. All plots: shaded line is the 95th percentile of data shuffled 1,000 times, using bootstrapping with replacement. Horizontal bars with corresponding colors indicate significant deviation (<i>p</i> < 0.05) from no laser stimulation. See also <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003518#pbio.3003518.s007" target="_blank">S7 Fig</a>.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_580b4485d28a802779d81ad01fcec6b2 |
| identifier_str_mv | 10.1371/journal.pbio.3003518.g003 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30714565 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations.Lilia Kukovska (22683586)Katharina A. Wilmes (22683589)Natsumi Y. Homma (22683592)Claudia Clopath (324706)Jasper Poort (22683595)BiochemistryNeuroscienceDevelopmental BiologyScience PolicyMental HealthBiological Sciences not elsewhere classifiedxlink "> inhibitionthree major factorsstrong competitive interactionsphoton imaging showedbalanced cortical activityprimary visual cortexsustained v1 activitycombined optogenetic activationv1 cells capturedmoderate pv activationmoderate activationvisual discriminationsexpressing cellsnonlinear activationdependent activationactivation strengthtask difficultystimulus onsetperceptual discriminationdifficult discriminationsdelineates conditionscircuit modelbehavioral effects<p><b>A)</b> Example of grating stimuli separated by 15° for difficult task (top), schematic of optogenetic manipulations activating only PV cells expressing ChR2 (middle), optogenetic stimulation timings for all four conditions aligned to stimulus onset (STIM ON) or offset (STIM OFF) (bottom). <b>B)</b> Normalized average discrimination performance, <i>d’</i>, <b>C)</b> normalized average rate of correct ‘go’ trials (hit rate), and <b>D)</b> normalized average rate of incorrect ‘no-go’ trials (false alarm rate), as a function of laser power for ‘entire’ window (black, <i>N</i> = 7, 24 sessions) and ‘early’ window (red, <i>N</i> = 8, 28 sessions) conditions. Data is normalized by subtracting the value of the 0 power level (see Methods). <b>E–G)</b> same as in B–D) but for ‘late1’ window (blue, <i>N</i> = 7, 25 sessions) and ‘late2’ window (green, <i>N</i> = 7, 25 sessions) conditions. All plots: shaded line is the 95th percentile of data shuffled 1,000 times, using bootstrapping with replacement. Horizontal bars with corresponding colors indicate significant deviation (<i>p</i> < 0.05) from no laser stimulation. See also <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003518#pbio.3003518.s007" target="_blank">S7 Fig</a>.</p>2025-11-25T18:37:26ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pbio.3003518.g003https://figshare.com/articles/figure/Stimulating_PV_cells_at_nonsilencing_levels_does_not_improve_performance_of_difficult_visual_discriminations_/30714565CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307145652025-11-25T18:37:26Z |
| spellingShingle | Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations. Lilia Kukovska (22683586) Biochemistry Neuroscience Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified xlink "> inhibition three major factors strong competitive interactions photon imaging showed balanced cortical activity primary visual cortex sustained v1 activity combined optogenetic activation v1 cells captured moderate pv activation moderate activation visual discriminations expressing cells nonlinear activation dependent activation activation strength task difficulty stimulus onset perceptual discrimination difficult discriminations delineates conditions circuit model behavioral effects |
| status_str | publishedVersion |
| title | Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations. |
| title_full | Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations. |
| title_fullStr | Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations. |
| title_full_unstemmed | Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations. |
| title_short | Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations. |
| title_sort | Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations. |
| topic | Biochemistry Neuroscience Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified xlink "> inhibition three major factors strong competitive interactions photon imaging showed balanced cortical activity primary visual cortex sustained v1 activity combined optogenetic activation v1 cells captured moderate pv activation moderate activation visual discriminations expressing cells nonlinear activation dependent activation activation strength task difficulty stimulus onset perceptual discrimination difficult discriminations delineates conditions circuit model behavioral effects |