Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations.

<p><b>A)</b> Example of grating stimuli separated by 15° for difficult task (top), schematic of optogenetic manipulations activating only PV cells expressing ChR2 (middle), optogenetic stimulation timings for all four conditions aligned to stimulus onset (STIM ON) or offset (STIM O...

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Bibliografische gegevens
Hoofdauteur:	Lilia Kukovska (22683586) (author)
Andere auteurs:	Katharina A. Wilmes (22683589) (author), Natsumi Y. Homma (22683592) (author), Claudia Clopath (324706) (author), Jasper Poort (22683595) (author)
Gepubliceerd in:	2025
Onderwerpen:	Biochemistry Neuroscience Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified xlink "> inhibition three major factors strong competitive interactions photon imaging showed balanced cortical activity primary visual cortex sustained v1 activity combined optogenetic activation v1 cells captured moderate pv activation moderate activation visual discriminations expressing cells nonlinear activation dependent activation activation strength task difficulty stimulus onset perceptual discrimination difficult discriminations delineates conditions circuit model behavioral effects
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Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations.

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