Antibody recognition of iRBC VSAs correlates negatively with the number of expressed DBL

Antibody recognition of iRBC VSAs correlates negatively with the number of expressed DBL

<p><b>α-</b><b>tags.</b><b>(A)</b> Plasma anti-AMA1 antibody levels in 54 samples (startDry n = 17, endDry n = 10, midWet n = 15, MAL n = 12) measured by ELISA. <b>(B)</b> Surface recognition of PfFCR3 iRBCs by plasma of 54 samples (startDry n = ...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Sukai Ceesay (3472853) (author)
مؤلفون آخرون: Martin Kampmann (5688443) (author), Lasse Votborg-Novél (20138013) (author), Helle Smedegaard Hansson (21519864) (author), Rasmus Weisel Jensen (15216781) (author), Manuela Carrasquilla (2897933) (author), Hamidou Cisse (21519867) (author), Louise Turner (55117) (author), Usama Dabbas (21519870) (author), Christina Ntalla (20138016) (author), Silke Bandermann (3611189) (author), Safiatou Doumbo (248618) (author), Didier Doumtabe (248621) (author), Aissata Ongoiba (248615) (author), Kassoum Kayentao (248612) (author), Boubacar Traore (248609) (author), Peter D. Crompton (9462929) (author), Thomas Lavstsen (75520) (author), Silvia Portugal (3385946) (author)
منشور في: 2025
الموضوعات:
Microbiology
Genetics
Immunology
Infectious Diseases
Computational Biology
Biological Sciences not elsewhere classified
Physical Sciences not elsewhere classified
used bioinformatic tools
upstream sequence type
main determinant limiting
achieved remains unknown
severe malaria cases
malaria cases compared
term infections may
seasonal transmission areas
clinical malaria occurs
clinical malaria cases
div >< p
plasmodium falciparum </
month dry season
binding pfemp1 dominated
asymptomatic carriers expressed
malaria transmission
clinical cases
asymptomatic carriers
falciparum </
subclinical infections
clinical presentation
wet season
dry season
binding phenotype
binding pfemp1
vars </
var </
wet seasons
transcripts attributed
transcript variation
transcript levels
sustain long
significant difference
shows circulation
sequenced expressed
reduced cytoadhesion
prolonged circulation
parasite ’
malian children
lower proportions
lower levels
larger proportion
infected erythrocytes
immune selection
host ’
host immunity
higher titers
gene expression
expresses fewer
domain composition
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