Surface-Engineered Filtration Device with Silver Nanoparticle–Silane Modifications for Enhanced Intracellular Delivery and Cell Transfection

Surface-Engineered Filtration Device with Silver Nanoparticle–Silane Modifications for Enhanced Intracellular Delivery and Cell Transfection

Despite promising therapeutic outcomes from cellular and gene therapies (CGTs), their widespread clinical application remains limited by the high costs and technical complexities of conventional transfection methods. We present an optimized filtration-driven membrane poration platform that addresses...

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Bibliographic Details
Main Author: Chuan-Hao Kuo (22058472) (author)
Other Authors: Sheng-Han Yang (22058475) (author), Zhen-Kai Lin (22058478) (author), Woei-Cherng Shyu (308328) (author), Long-Bin Jeng (499919) (author), Chih-Sheng Chiang (14977287) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Medicine
Cell Biology
Molecular Biology
Biotechnology
Space Science
Biological Sciences not elsewhere classified
Physical Sciences not elsewhere classified
scale screening applications
optimizing membrane disruption
functional plasmid dna
enhanced intracellular delivery
diverse cargo types
derived stem cells
addresses key limitations
silver ion effects
introduces hydrophobic properties
improve cell recovery
engineered filtration device
conventional transfection methods
optimized system demonstrates
conventional methods
optimized filtration
system achieves
silver nanoparticles
hydrophobic surfaces
cell passage
optimized configuration
yield using
unmodified filters
technical complexities
silane coating
physical interactions
limited laboratories
high costs
gene therapies
filter paper
cgts ),
adscs ).
accessible alternative
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