Figure 7 from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

Figure 7 from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

<p>Efficacy of combined dasatinib and trametinib on <i>ex vivo</i> brain slice preparations. <b>A,</b> Coronal slices of normal mouse brain, counterstained with Hoechst 33342 (aqua), are implanted in the pontine region with ICR-B169 parental cells, stained with human nu...

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1. Verfasser: Elisa Izquierdo (15110795) (author)
Weitere Verfasser: Diana M. Carvalho (5608127) (author), Alan Mackay (20972) (author), Sara Temelso (13755357) (author), Jessica K.R. Boult (14936256) (author), Giulia Pericoli (15121517) (author), Elisabet Fernandez (15121520) (author), Molina Das (15121523) (author), Valeria Molinari (15110798) (author), Yura Grabovska (14234303) (author), Rebecca F. Rogers (14941192) (author), Maria Antonietta Ajmone-Cat (15121526) (author), Paula Z. Proszek (14997741) (author), Mark Stubbs (1353564) (author), Sarita Depani (15121529) (author), Patricia O'Hare (15121532) (author), Lu Yu (14946738) (author), Georgia Roumelioti (15121535) (author), Jyoti S. Choudhary (9927836) (author), Matthew Clarke (3550808) (author), Amy R. Fairchild (15110801) (author), Thomas S. Jacques (15117937) (author), Richard G. Grundy (15018659) (author), Lisa Howell (15121538) (author), Susan Picton (3813571) (author), Jenny Adamski (11420832) (author), Shaun Wilson (5013728) (author), Juliet C. Gray (15121541) (author), Bassel Zebian (5986940) (author), Lynley V. Marshall (15110912) (author), Fernando Carceller (14945229) (author), Jacques Grill (15015216) (author), Maria Vinci (15121544) (author), Simon P. Robinson (14934318) (author), Michael Hubank (15104113) (author), Darren Hargrave (15016889) (author), Chris Jones (25458) (author)
Veröffentlicht: 2025
Schlagworte:
Cancer
Therapeutic Research and Development
CNS Cancers
Gliomas, Glioblastomas
Pediatric Cancers
Small Molecule Agents
Kinase inhibitors
Translational Research
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