A-B. Differential expression heatmap of IRF4 and ELANE genes, grouped by high and low expression of disease-associated features.

<p>Red represents positive correlation, blue represents negative correlation. Left panel: IRF4, Right panel: ELANE. “HIGH” and “LOW” indicate expression levels of disease-associated genes. C-D. Correlation Matrix Chart: Illustrating the correlation between disease-related genes and target gene...

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Bibliographic Details
Main Author:	Min-xiao Wang (20868922) (author)
Other Authors:	Chang-sheng Liao (18591969) (author), Xue-qin Wei (20868925) (author), Yu-qin Xie (20868928) (author), Peng-fei Han (694841) (author), Yan-hui Yu (20868931) (author)
Published:	2025
Subjects:	Cell Biology Genetics Molecular Biology Marine Biology Infectious Diseases Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified targeted interventions directed svm )&# 8212 support vector machine may also guide hematopoietic stem cells exploring therapeutic strategies downloaded three datasets core predictive models provide new insights revealed significant differences results independently using ensure data consistency differentially expressed genes provide novel insights xlink "> initially study sheds light performed differential analysis enhance prediction accuracy clinical treatment strategies two key genes key pathogenic genes differential gene expression xlink "> key genes significant changes prediction results novel perspective gene groups data preprocessing expression levels expression analysis identify genes genes associated findings provide validation set ultimate goal training sets training set thereby integrating study aims robust list random forest pathological process particular focus notably downregulated myelodysplastic syndromes mechanisms underlying lasso regression gse19429 dataset figure illustrates enrichment analysis effective treatments disease initiation disease features disease diagnosis disease characteristics depth analysis delve deeper control group comprehensive evaluation combat algorithm bioinformatics analysis analysis workflow
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A-B. Differential expression heatmap of IRF4 and ELANE genes, grouped by high and low expression of disease-associated features.

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