Nitrite accumulation as a surrogate for NO generation.

Nitrite accumulation as a surrogate for NO generation.

<p>Effect of intermittent glucose and glucose/fructose exposure on nitrite accumulation at NG, IG and HG test conditions (n = 12–14; ***P<0.001 Bonferroni post-test compared to glucose only control at equivalent concentrations).</p>

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Bibliographic Details
Main Author:	Maria Luisa Fiorello (12542737) (author)
Other Authors:	Andrew T. Treweeke (12542740) (author), David P. Macfarlane (12542743) (author), Ian L. Megson (493664) (author)
Published:	2022
Subjects:	Biochemistry Medicine Cell Biology Physiology Ecology Cancer Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified “ meals ”. physiologically relevant concentrations mimics mealtime consumption induced cardiovascular disease bioenergetic parameters using atherosclerotic disease associated approximately 90 %) without substituted fructose metabolic activity induced key metabolic findings div >< p nitric oxide production hy926 endothelial cells healthy endothelial function glucose alone failed cultured endothelial cells intermittent fructose induced induce endothelial dysfunction relatively low proportion 25 mm ), 1 mm fructose bioenergetics </ p nitric oxide endothelial function endothelial cells 1 mm metabolic function vitro </ small proportion intermittent exposure metabolic analyser circulating fructose cells treated cells exposed cells experienced metabolic impact treatment regimen substantial reduction similar change parallel experiments oxidative stress marked increase major implications intermediate glucose fold increase exquisitely sensitive equal concentration either concentration cell markers carbohydrate load 50 h 5 mm
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