Schematic representation of G1 cell cycle arrest inhibited by CsA in gingival fibroblasts.

CsA induces the downregulation of SMAD3 and SMAD4, which leads to a decrease in P21. CsA also induces the upregulation of CDC25A, CYCLIN E, phosphorylated CDK2 and phosphorylated RB, which results in the inhibition of G1 cell cycle arrest. Light blue (factors of G<...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Reiri Takeuchi (20460788) (author)
مؤلفون آخرون:	Takatoshi Nomura (2363839) (author), Manabu Yaguchi (20460791) (author), Noriko Kuwahara (20460794) (author), Yuta Amino (20460797) (author), Chieko Taguchi (8744814) (author), Itaru Suzuki (1546066) (author), Haruka Suzuki (1711804) (author), Teruaki Nagashima (20460800) (author), Kazumune Arikawa (8744817) (author), Yuichiro Okada (20460803) (author), Takato Nomoto (20460806) (author), Koichi Hiratsuka (20460809) (author)
منشور في:	2024
الموضوعات:	Cell Biology Molecular Biology Biotechnology Developmental Biology Cancer Hematology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified without 200 ng western blot analysis fetal bovine serum div >< p cell cycle phases cell cycle arrest induced gingival overgrowth gingival overgrowth caused human gingival fibroblasts cell cycle regulators protein expression levels increased fibroblast proliferation cyclin e1 </ mrna expression levels protein expression gingival fibroblasts cyclin e1 cell proliferation gingival tissues also increased increases levels significantly increased rb1 </ p53 </ p27 </ myc </ atr </ atm </ quantitative pcr healthy donors damage restoration cells detect 166 nm
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Schematic representation of G<sub>1</sub> cell cycle arrest inhibited by CsA in gingival fibroblasts.

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