$Unveiling the Structure of Anhydrous Sodium Valproate with 3D Electron Diffraction and a Facile Sample Preparation Workflow$

Unveiling the Structure of Anhydrous Sodium Valproate with 3D Electron Diffraction and a Facile Sample Preparation Workflow

Understanding the structure of an active pharmaceutical ingredient is essential for gaining insights into its physicochemical properties. Sodium valproate, one of the most effective antiepileptic drugs, was first approved for medical use in 1967. However, the structure of its anhydrous form has rema...

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Bibliographic Details
Main Author:	Jiaoyan Xu (5844680) (author)
Other Authors:	Vivek Srinivas (3526358) (author), Rohit Kumar (2177842) (author), Laura Pacoste (21399538) (author), Yiwang Guo (5598620) (author), Taimin Yang (5754359) (author), Changquan Calvin Sun (812250) (author), Martin Högbom (1498489) (author), Xiaodong Zou (1414267) (author), Hongyi Xu (1414264) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Biotechnology Developmental Biology Cancer Infectious Diseases Computational Biology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified effective antiepileptic drugs active pharmaceutical ingredient valproate polyhedral chains 3d ed analysis anhydrous sodium valproate 3d electron diffraction sodium valproate 3d ed ray diffraction anhydrous form electron beams transfer workflow sufficient size successfully determined room temperature robust framework results provide remained unresolved protected atmosphere physicochemical properties medical use greatly enhancing gaining insights first approved extremely sensitive em grids degrade quickly current challenges crystal x assisted cryo
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Unveiling the Structure of Anhydrous Sodium Valproate with 3D Electron Diffraction and a Facile Sample Preparation Workflow

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