TAX1BP1 is involved in the p22-induced degradation of IFNAR1.

<p>(A) HEK293T cells were cotransfected with the plasmids expressing HA-NBR1, -CALCOCO2, -TAX1BP1, -p62, -OPTN, -NIX, or -TOLLIP, and Flag-p22, and then lysed for co-IP using the anti-Flag MAb, followed by western blotting analysis using the indicated antibodies. (B) HEK293T cells were cotrans...

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Autor Principal:	Haojie Ren (9353596) (author)
Outros autores:	Yanjin Wang (1375503) (author), Lian-Feng Li (14680123) (author), Lan-Fang Shi (21728677) (author), Yu-He Ma (21728680) (author), Jun-Hao Fan (21728683) (author), Xiao-Ya Pan (21728686) (author), Han-Cheng Shao (21728689) (author), Yuhang Zhang (3144870) (author), Shichong Han (665820) (author), Bo Wan (212083) (author), Hua-Ji Qiu (3967025) (author), Gai-Ping Zhang (8616999) (author), Su Li (294188) (author), Wen-Rui He (21728692) (author)
Publicado:	2025
Subjects:	Biophysics Biochemistry Medicine Microbiology Genetics Molecular Biology Immunology Developmental Biology Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified viral structural proteins porcine alveolar macrophages novel theoretical basis devastating disease epidemic african swine fever >- triggered activation >&# 946 ;</ ifn receptor 1 host antiviral responses div >< p binding protein 1 stat signaling pathway asfv p22 promotes signaling pathway ifn -< antiviral therapies via </ transmembrane region thereby facilitating signal transducer severely hindered results indicated p22 protein mediated degradation may contribute janus kinase initial step findings clarify deciphered despite causative agent biological functions biological characteristics autophagic degradation
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TAX1BP1 is involved in the p22-induced degradation of IFNAR1.

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