Second-step adaptive mutants tend to improve respiration performance and not fermentation performance.

<p><b>(A)</b> Performance calculation in each growth phase. Respiration performance (per hour) is calculated as the difference between a mutant’s 2-Day and 1-Day fitness, divided by 24 h. To calculate fermentation performance (per hour), we remove 4 h of 1-Day fitness that is due t...

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Bibliographic Details
Main Author:	Grant Kinsler (4258783) (author)
Other Authors:	Yuping Li (157863) (author), Gavin Sherlock (827) (author), Dmitri A. Petrov (8031335) (author)
Published:	2024
Subjects:	Biophysics Biochemistry Microbiology Genetics Molecular Biology Neuroscience Evolutionary Biology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified several growth phases condition show patterns pleiotropically adaptive mutations xlink "> evolution genes may serve conducted barcoded second common throughout adaptation adaptively pleiotropic benefits microbial evolution experiments step mutations show step evolution experiment step mutations identified evolution experiments step mutations also identified step clones drive evolution yeast reveals vast majority results suggest resolution two rare feature provide large pleiotropic adaptation organism due natural selection mutants isolated molecular basis mitochondrial function isolated hundreds gradual process early steps early stages become exhausted asked whether acquiring smaller
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Second-step adaptive mutants tend to improve respiration performance and not fermentation performance.

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