Functional analysis of primate CYP4B1 orthologs.

<p><b>(A)</b> The cDNAs of CYP4B1 enzymes from different primate clades, including prosimians, Old World monkeys (OWMs), gibbon, great apes, and humans were cloned into a lentiviral expressing vector upstream of an IRES-Puro site. CMV: CMV promoter; LTR: long terminal repeat; RRE:...

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מחבר ראשי:	Saskia Hüsken (21616072) (author)
מחברים אחרים:	Annika Röder (21616075) (author), Johannes Ptok (9283781) (author), Anne E. Meyer (21616078) (author), Mats Georg (21380052) (author), Yannick Schwarz (21616081) (author), Christian Roos (141269) (author), Kerstin Mätz-Rensing (365237) (author), Michael C. Hutter (2372869) (author), Doreen M. Floss (21616084) (author), Allan E. Rettie (219933) (author), Marco Girhard (3400892) (author), Helmut Hanenberg (140467) (author), Constanze Wiek (140463) (author)
יצא לאור:	2025
נושאים:	Biochemistry Microbiology Genetics Molecular Biology Neuroscience Evolutionary Biology Infectious Diseases Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified exon deletion found closely related species 14 primate genera human liver cells hydroxylate lauric acid amino acid analysis div >< p native human cyp4b1 tested cyp4b1 orthologs lauric acid cyp4b1 orthologs human evolution human enzymes functional analysis also tested inactivating cyp4b1 gorilla cyp4b1 cyp4b1 inactivation cyp4b1 enzymes v71g specific ultimately improve perilla ketone negative impact genetic changes evolutionary trigger endobiotic substrates coli </ clear indication
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Functional analysis of primate CYP4B1 orthologs.

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