Table 2_How artificial intelligence can enable personalized mesenchymal stem cell–based therapeutic strategies in systemic lupus erythematosus.docx
<p>Mesenchymal Stromal Cells (MSCs) are increasingly recognized as promising candidates for treating Systemic Lupus Erythematosus (SLE) due to their immunomodulatory and regenerative properties. However, their therapeutic efficacy remains inconsistent, largely due to the heterogeneity of MSC o...
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2025
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| _version_ | 1849927623214366720 |
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| author | Sushmitha Rajeev Kumar (22687190) |
| author2 | Khor Kai He (22687193) Yogeswaran Lokanathan (6931790) Anand Gaurav (3137511) Khatijah Yusoff (2467768) M. Fatima Macedo (6792557) Subha Bhassu (416376) |
| author2_role | author author author author author author |
| author_facet | Sushmitha Rajeev Kumar (22687190) Khor Kai He (22687193) Yogeswaran Lokanathan (6931790) Anand Gaurav (3137511) Khatijah Yusoff (2467768) M. Fatima Macedo (6792557) Subha Bhassu (416376) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sushmitha Rajeev Kumar (22687190) Khor Kai He (22687193) Yogeswaran Lokanathan (6931790) Anand Gaurav (3137511) Khatijah Yusoff (2467768) M. Fatima Macedo (6792557) Subha Bhassu (416376) |
| dc.date.none.fl_str_mv | 2025-11-26T06:31:33Z |
| dc.identifier.none.fl_str_mv | 10.3389/fimmu.2025.1654117.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Table_2_How_artificial_intelligence_can_enable_personalized_mesenchymal_stem_cell_based_therapeutic_strategies_in_systemic_lupus_erythematosus_docx/30718550 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Genetic Immunology machine learning stem cells lupus genetic modifications personalised medicine precision therapeutics |
| dc.title.none.fl_str_mv | Table 2_How artificial intelligence can enable personalized mesenchymal stem cell–based therapeutic strategies in systemic lupus erythematosus.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <p>Mesenchymal Stromal Cells (MSCs) are increasingly recognized as promising candidates for treating Systemic Lupus Erythematosus (SLE) due to their immunomodulatory and regenerative properties. However, their therapeutic efficacy remains inconsistent, largely due to the heterogeneity of MSC origins, culture conditions, cell quality, host immune interactions, and the influence of immunosuppressive treatments. Artificial Intelligence (AI) offers powerful tools to address these challenges by optimising MSC modification and application. This review explores how AI can identify optimal genetic and epigenetic targets, predict MSC behaviour under different environmental and priming conditions, and design personalise therapies tailored to individual patients. Moreover, AI enables the analysis of extensive datasets to refine dosing strategies and improve the integration of MSC therapy with immunosuppressants. By enhancing the precision, consistency, and personalisation of MSC-based interventions, AI has the potential to significantly improve therapeutic outcomes in SLE, advancing the field toward more effective and patient-centred autoimmune disease management.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_6847b771e5c41a2402fdc8512cc81da9 |
| identifier_str_mv | 10.3389/fimmu.2025.1654117.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30718550 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Table 2_How artificial intelligence can enable personalized mesenchymal stem cell–based therapeutic strategies in systemic lupus erythematosus.docxSushmitha Rajeev Kumar (22687190)Khor Kai He (22687193)Yogeswaran Lokanathan (6931790)Anand Gaurav (3137511)Khatijah Yusoff (2467768)M. Fatima Macedo (6792557)Subha Bhassu (416376)Genetic Immunologymachine learningstem cellslupusgenetic modificationspersonalised medicineprecision therapeutics<p>Mesenchymal Stromal Cells (MSCs) are increasingly recognized as promising candidates for treating Systemic Lupus Erythematosus (SLE) due to their immunomodulatory and regenerative properties. However, their therapeutic efficacy remains inconsistent, largely due to the heterogeneity of MSC origins, culture conditions, cell quality, host immune interactions, and the influence of immunosuppressive treatments. Artificial Intelligence (AI) offers powerful tools to address these challenges by optimising MSC modification and application. This review explores how AI can identify optimal genetic and epigenetic targets, predict MSC behaviour under different environmental and priming conditions, and design personalise therapies tailored to individual patients. Moreover, AI enables the analysis of extensive datasets to refine dosing strategies and improve the integration of MSC therapy with immunosuppressants. By enhancing the precision, consistency, and personalisation of MSC-based interventions, AI has the potential to significantly improve therapeutic outcomes in SLE, advancing the field toward more effective and patient-centred autoimmune disease management.</p>2025-11-26T06:31:33ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fimmu.2025.1654117.s001https://figshare.com/articles/dataset/Table_2_How_artificial_intelligence_can_enable_personalized_mesenchymal_stem_cell_based_therapeutic_strategies_in_systemic_lupus_erythematosus_docx/30718550CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307185502025-11-26T06:31:33Z |
| spellingShingle | Table 2_How artificial intelligence can enable personalized mesenchymal stem cell–based therapeutic strategies in systemic lupus erythematosus.docx Sushmitha Rajeev Kumar (22687190) Genetic Immunology machine learning stem cells lupus genetic modifications personalised medicine precision therapeutics |
| status_str | publishedVersion |
| title | Table 2_How artificial intelligence can enable personalized mesenchymal stem cell–based therapeutic strategies in systemic lupus erythematosus.docx |
| title_full | Table 2_How artificial intelligence can enable personalized mesenchymal stem cell–based therapeutic strategies in systemic lupus erythematosus.docx |
| title_fullStr | Table 2_How artificial intelligence can enable personalized mesenchymal stem cell–based therapeutic strategies in systemic lupus erythematosus.docx |
| title_full_unstemmed | Table 2_How artificial intelligence can enable personalized mesenchymal stem cell–based therapeutic strategies in systemic lupus erythematosus.docx |
| title_short | Table 2_How artificial intelligence can enable personalized mesenchymal stem cell–based therapeutic strategies in systemic lupus erythematosus.docx |
| title_sort | Table 2_How artificial intelligence can enable personalized mesenchymal stem cell–based therapeutic strategies in systemic lupus erythematosus.docx |
| topic | Genetic Immunology machine learning stem cells lupus genetic modifications personalised medicine precision therapeutics |