The R203M and D377Y mutation of N protein inhibited the colocalization with RIG-I.

<p>Caco-2 cells were co-transfected with plasmids encoding different mutated N protein and HA-tagged RIG-I protein for 24 h and then infected with SARS-CoV-2 GFP/ΔN (MOI = 5) for 48 h. Nucleus marker DAPI (blue), HA-tagged RIG-I protein (yellow), GFP- SARS-CoV-2 GFP/ΔN (green) and Flag- mutate...

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Main Author:	Yongkui Li (5642561) (author)
Other Authors:	Moran Li (1837711) (author), Heng Xiao (489521) (author), Feng Liao (458424) (author), Miaomiao Shen (7916312) (author), Weiwei Ge (7257905) (author), Junxian Ou (10801050) (author), Yuqing Liu (103879) (author), Lumiao Chen (20598543) (author), Yue Zhao (186573) (author), Pin Wan (3622859) (author), Jinbiao Liu (576171) (author), Jun Chen (4238) (author), Xianwu Lan (20598546) (author), Shaorong Wu (13907973) (author), Qiang Ding (295913) (author), Geng Li (312002) (author), Qiwei Zhang (277241) (author), Pan Pan (636461) (author)
Published:	2025
Subjects:	Biochemistry Medicine Microbiology Molecular Biology Evolutionary Biology Immunology Cancer Mental Health Infectious Diseases Virology Biological Sciences not elsewhere classified mediated interferon induction mediated antiviral signaling intracellular signal regulation ifn -&# 946 viral genome assembly 2 &# 8201 viral rna compared 2 infection therein viral protein mutations n protein mutations viral rna viral evolution n protein two mutations 2 participates 2 infectivity xlink "> well understood virus evolution thus alter suppressive activity study helps studies indicate site 377 site 203 modify virus irf3 phosphorylation inhibitory impact immune interference host interactions effectively attenuating biological function binding activity
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The R203M and D377Y mutation of N protein inhibited the colocalization with RIG-I.

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