Table 1_Fibroblast-like synoviocytes mediate the generation of soluble PD-1 in an MMP-9-dependent manner: a novel target therapy for rheumatoid arthritis.docx

Table 1_Fibroblast-like synoviocytes mediate the generation of soluble PD-1 in an MMP-9-dependent manner: a novel target therapy for rheumatoid arthritis.docx

Introduction<p>Dysregulated T cell homeostasis leading to enhanced immune responses is a critical pathogenic mechanism in rheumatoid arthritis (RA). Programmed cell death protein 1 (PD-1) is a crucial immune checkpoint that modulates T cell activity. Soluble PD-1 (sPD-1) may contribute to the...

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Main Author: Chao Yang (174810) (author)
Other Authors: Miao Ma (8351802) (author), Kangjie Yu (8620416) (author), Yi Wang (32470) (author), Yuting Zhang (337082) (author), Yan Shen (12156) (author), Jun Wang (5906) (author), Xiaoke Wang (548086) (author), Lulu Luo (11884589) (author), Ya Zhao (807581) (author)
Published: 2025
Subjects:
Genetic Immunology
rheumatoid arthritis (RA)
fibroblast-like synoviocytes (FLS)
soluble PD-1
MMP-9
PD-L1-MSA
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