Full-length DDR2-Y740C and DDR2-L610P are constitutively active in the absence of collagen stimulation.

<p><b>A. Left</b>, Schematic of the DDR2 architecture, showing the extracellular DS domain followed by a DS-like domain, an extracellular juxtamembrane (EJM) region and a TM domain. The intracellular part is composed of a flexible intracellular juxtamembrane (IJM) region and a cata...

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Xehetasun bibliografikoak
Egile nagusia:	Ziteng Hao (22647882) (author)
Beste egile batzuk:	Birgit Leitinger (111622) (author)
Argitaratua:	2025
Gaiak:	Biophysics Biochemistry Cell Biology Molecular Biology Biotechnology Immunology Infectious Diseases Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified substrate phosphorylation rates mechanistic studies addressing key catalytic residues increased catalytic rates autosomal dominant manner atp binding affinity independent constitutive autophosphorylation missense variant bypasses y740c kinase constructs wt ddr2 kinase y740c kinase substituted variant missense mutations enhanced autophosphorylation ddr2 kinase ddr1 kinase y740c displayed wt ddr2 soluble wt xlink "> unphosphorylated ddr2 structural explanation skin fusion previously hypothesised mammalian cells length proteins keloid plaques function mechanism enzyme kinetics corneal vascularisation cinotti variants cinotti syndrome cause disease autoinhibitory constraints
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Full-length DDR2-Y740C and DDR2-L610P are constitutively active in the absence of collagen stimulation.

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