In vivo impact of Q103A mutation in a murine dermonecrosis model.

(A) Mean lesions size (mm²) were measured in mice infected with S. aureus SH10004X strains expressing either WT or Q103A-mutated FnBPA at day 7 post-infection. (B) Bacterial load per biopsy was quantified by CFU counts at day 7 post-infection. Each dot represents an indiv...

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Бібліографічні деталі
Автор:	Chiara Motta (16015211) (author)
Інші автори:	Mary Turley (22756239) (author), Giulia Barbieri (7055000) (author), Agata Famà (10974896) (author), Francesco Coppolino (8615506) (author), Elisa Bellan Menegussi (22756242) (author), Joan A. Geoghegan (7934549) (author), Concetta Beninati (166964) (author), Angelica Pellegrini (12472515) (author), Giampiero Pietrocola (424821) (author)
Опубліковано:	2025
Предмети:	Biochemistry Medicine Microbiology Cell Biology Genetics Molecular Biology Immunology Cancer Infectious Diseases Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified new virulence strategy murine infection model life threatening diseases human factor xiii cause different types broader physiological relevance evade host immunity lower bacterial loads bacterial surface proteins new pathogenic mechanism form covalent complexes host protein complexes uses host transglutaminases fibronectin binding protein staphylococcus aureus </ mediated fibrin crosslinking binding protein mediated crosslinking aureus </ host tissues stabilizing bacterial latch mechanism vivo </ uses vwbp covalent fnbpa various tissues type strain skin lesions similar pathway retained non results show opportunistic pathogen ogen ). n1 subdomain less virulent fibrin matrices extracellular matrix effective adhesion covalently anchor classical dock
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<i>In vivo</i> impact of Q103A mutation in a murine dermonecrosis model.

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