Enantiocomplementary Access to Silicon-Stereogenic Silacyclohexenones via Ene-Reductase-Catalyzed Desymmetrization of Silacyclohexadienones

Silicon-stereogenic organosilicon compounds have garnered ever-increasing attention and found widespread applications in various areas as functional molecules. The biocatalytic synthesis of these entities has been scarcely reported and is limited to the use of hydrolases, which suffer from low yield...

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المؤلف الرئيسي:	Xiaofan Wu (8629848) (author)
مؤلفون آخرون:	Fei Hou (521771) (author), Li Zhang (8200) (author), Qiong Wu (84327) (author), Zedu Huang (2017120) (author), Fener Chen (1491025) (author)
منشور في:	2025
الموضوعات:	Biochemistry Biotechnology Ecology Sociology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified unique stereoelectronic features mostly ≥ 97 found widespread applications 88 %), along complementary enantioselectivities displayed stereogenic organosilicon compounds catalyzed desymmetrization process catalyzed desymmetrization superb enantioselectivities stereogenic silacyclohexenones stereogenic organosilanes catalyzed synthesis various areas unprecedented non type enzyme shed light scarcely reported reversed enantioselectivity offers expedited molecular dynamics low yields isolated yields insufficient stereoselectivities increasing attention immense potential high conversions garnered ever functional molecules enzyme catalysis enhanced reactivity enantiocomplementary reduction enantiocomplementary access ee ). diverse array disubstituted silacyclohexenones could likely biocatalytic synthesis also showcases 99 %)
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Enantiocomplementary Access to Silicon-Stereogenic Silacyclohexenones via Ene-Reductase-Catalyzed Desymmetrization of Silacyclohexadienones

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