Genomic structures of Ad11-muFiber.

<p>For de-targeting to CD46, the CD46-binding motif in the fiber knob of Ad11-E2F-∆24 was replaced with a GS linker.</p> <p>(TIF)</p>

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書誌詳細
第一著者:	Masahisa Hemmi (21601907) (author)
その他の著者:	Midori Yamashita (21601910) (author), Yoshiko Shimizu (171960) (author), Shinsuke Nakao (52048) (author)
出版事項:	2025
主題:	Medicine Cell Biology Molecular Biology Pharmacology Biotechnology Ecology Immunology Cancer Mental Health Hematology Infectious Diseases Virology Chemical Sciences not elsewhere classified shown clinical benefit promising therapeutic approach minimum binding affinity ad11 antibody clones killing cancer cells cancer cells inhibit binding cancer types cancer treatment vec ), unique modality talimogene laherparepvec several limitations selectively replicate prevent use oncolytic viruses natural receptor multifaceted mechanisms intravenous administration intratumoral administration human erythrocytes ensuring safe class agent broader range advanced melanoma ad11 fibers
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