Pharmacologic modification of the tumor microenvironment reduces astrogliosis and harmonizes astrocytic GLT1 expression.

(A) In RGD-treated mice less Gfap+, reactive astrocytes are detected in the astrocytic ring around the TC and more Gfap+, reactive astrocytes are present in the TC compared to controls. (B) Quantification of percentage of area occupied by Gfap+, reactiv...

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主要作者:	Mitrajit Ghosh (462069) (author)
其他作者:	Paulina Pilanc-Kudlek (18100568) (author), Szymon Baluszek (16530426) (author), Karol Jacek (22421714) (author), Katarzyna Poleszak (15218617) (author), Paulina Szadkowska (15218614) (author), Anna M. Lenkiewicz (10186700) (author), Bartłomiej Gielniewski (807489) (author), Aleksandra Ellert-Miklaszewska (345432) (author), Maria G. Castro (12574728) (author), Bozena Kaminska (65469) (author)
出版:	2025
主题:	Cell Biology Genetics Neuroscience Cancer Biological Sciences not elsewhere classified Information Systems not elsewhere classified designer rgd peptide present distinct morphological gene signatures associated spatial transcriptomics combined spatial transcriptomics allow combined spatial transcriptomics tme ), revealed pharmacologically induced modification multiple immunofluorescent staining astrocytes become activated taas allows adaptation associated astrocyte subpopulations interactions within tme div >< p demonstrate distinct morphology different brain regions visualize taas heterogeneity associated astrocytes distinct localization spatial distribution spatial architecture various subpopulations various regions multiple roles induced heterogeneity gbm ), different roles brain cells astrocytes comprise taas reflected taas based specific roles specific context specialized functionalities slc1a2 </ segregated areas poorly known microglia communications local milieu identified subtypes hidden functionalities glutamate transporter functional properties
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Pharmacologic modification of the tumor microenvironment reduces astrogliosis and harmonizes astrocytic GLT1 expression.

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