Coordinated Residue Motions at the Enzyme–Substrate Interface Promote DNA Translocation in Polymerases

The translocation of DNA in polymerase (Pol) enzymes is a critical step for Pol-mediated nucleic acid polymerization, essential for storing and transmitting genetic information in all living organisms. During this process, the newly elongated double-stranded DNA has to shift along the Pol enzyme to...

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Bibliographic Details
Main Author:	Alessia Visigalli (21561889) (author)
Other Authors:	Enrico Trizio (11373919) (author), Luigi Bonati (8661954) (author), Pietro Vidossich (1275279) (author), Michele Parrinello (240049) (author), Marco De Vivo (7358288) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Medicine Cell Biology Genetics Molecular Biology Biotechnology Cancer Computational Biology Astronomical and Space Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified transmitting genetic information positively charged residues offer new avenues every catalytic cycle equilibrium molecular dynamics aided reactive center coordinated residue motions two dna strands mechanism relies precisely newly elongated double dna polymerase η stranded dna translocation stranded dna coordinated way translocation mechanism dynamic mechanism dna polymerization template strand occur via occur recurrently living organisms initial configuration growing strand critical step atomistic level asynchronous along add one
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Coordinated Residue Motions at the Enzyme–Substrate Interface Promote DNA Translocation in Polymerases

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