<b>Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score</b>

<b>Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score</b>

<p dir="ltr">Polygenic scores strongly predict type 1 diabetes risk, but most scores were developed in European-ancestry populations. In this study, we leveraged recent multi-ancestry genome-wide association studies to create a type 1 diabetes multi-ancestry polygenic score (T1D MAPS...

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Autor principal: Aaron J. Deutsch (15992555) (author)
Altres autors: Andrew S. Bell (22377322) (author), Dominika A. Michalek (22377324) (author), Adam B. Burkholder (22377327) (author), Stella Nam (22377328) (author), Raymond J. Kreienkamp (22377330) (author), Seth A. Sharp (22377331) (author), Alicia Huerta-Chagoya (739312) (author), Ravi Mandla (15992561) (author), Ruth Nanjala (14709606) (author), Yang Luo (350920) (author), Richard A. Oram (21614925) (author), Jose C. Florez (114792) (author), Suna Onengut-Gumuscu (282049) (author), Stephen S. Rich (110262) (author), Maggie C. Y. Ng (190281) (author), Alison A. Motsinger-Reif (22377334) (author), Alisa K. Manning (110227) (author), Josep M. Mercader (114767) (author), Miriam S. Udler (15992566) (author)
Publicat: 2025
Matèries:
Other biological sciences not elsewhere classified
Type 1 Diabetes
Genetics
Statistical Genetics
Human Leukocyte Antigen (HLA)
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