The values for <i>k</i><sub>cat</sub> and <i>K</i><sub>M</sub> are sourced from [19].

The values for <i>k</i><sub>cat</sub> and <i>K</i><sub>M</sub> are sourced from [19].

<p>All the IC<sub>50</sub> values for the wild-type, G250E, E255K, E255V and T315I are from [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012570#pcbi.1012570.ref042" target="_blank">42</a>]. The IC<sub>50</sub&...

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Bibliographic Details
Main Author: J. Roadnight Sheehan (20141887) (author)
Other Authors: Astrid S. de Wijn (20141890) (author), Thales Souza Freire (20141893) (author), Ran Friedman (500639) (author)
Published: 2024
Subjects:
Genetics
Pharmacology
Biotechnology
Evolutionary Biology
Cancer
Hematology
Infectious Diseases
Plant Biology
Virology
Chemical Sciences not elsewhere classified
product formation rate
major clinical obstacle
div >< p
chronic myeloid leukaemia
line treatment occurs
three abl1 inhibitors
different abl1 inhibitors
contest using fold
computational dynamic model
guide treatment choice
enzyme inhibition treatment
abl1 inhibitors
abl1 enzyme
treatment selection
various mutation
selecting treatments
relative decrease
positive impact
often seen
often guided
new parameter
model based
inhibitor combinations
fully known
difficult task
could increase
communicable diseases
common cause
better indicator
approximately one
&# 8220
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