Dual Role of Anionic Lipids in Amyloid Aggregation

Neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s, affect millions worldwide and share a common feature: the aggregation of intrinsically disordered proteins into toxic oligomers that interact with cell membranes. In Alzheimer’s disease (AD), amyloid-beta (Aβ) peptides a...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Meenal Jain (19948084) (author)
مؤلفون آخرون:	Silvina Matysiak (1559413) (author)
منشور في:	2024
الموضوعات:	Biophysics Biochemistry Cell Biology Molecular Biology Neuroscience Pharmacology Biotechnology Sociology Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified two competing factors mixed bilayer compositions intrinsically disordered proteins affect millions worldwide mixed lipid bilayers enhanced lipid demixing various neurodegenerative diseases model amyloidogenic peptide grained molecular dynamics 22 </ sub 16 </ sub ps – 90 ps – 100 mediated peptide aggregation ad ), amyloid anionic lipids led peptide aggregation kinetics anionic lipids lipid membranes aggregation dynamics neurodegenerative disorders interaction kinetics amyloidogenic peptides zwitterionic lipids representative anionic ps clusters protein aggregation promoted aggregation β ’ used phosphatidylserine used coarse understanding membrane toxic oligomers study interactions plasma membranes peptides accumulate parkinson ’ ordered aggregates membranes enriched knowledge gap huntington ’ higher percentages findings contribute early stages complex interplay common feature characterize experimentally cell membranes alzheimer ’
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Dual Role of Anionic Lipids in Amyloid Aggregation

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