Figure 2 from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

Figure 2 from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

<p><i>PIK3R1</i> and <i>NF1</i> mutations drive the sensitivity of DIPG cells to trametinib. <b>A,</b> Cartoon representing the protein domains of <i>PIK3R1</i> showing the mutant residue for the observed hotspot N564D mutation observed in ICR-B1...

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Detalhes bibliográficos
Autor principal:	Elisa Izquierdo (15110795) (author)
Outros Autores:	Diana M. Carvalho (5608127) (author), Alan Mackay (20972) (author), Sara Temelso (13755357) (author), Jessica K.R. Boult (14936256) (author), Giulia Pericoli (15121517) (author), Elisabet Fernandez (15121520) (author), Molina Das (15121523) (author), Valeria Molinari (15110798) (author), Yura Grabovska (14234303) (author), Rebecca F. Rogers (14941192) (author), Maria Antonietta Ajmone-Cat (15121526) (author), Paula Z. Proszek (14997741) (author), Mark Stubbs (1353564) (author), Sarita Depani (15121529) (author), Patricia O'Hare (15121532) (author), Lu Yu (14946738) (author), Georgia Roumelioti (15121535) (author), Jyoti S. Choudhary (9927836) (author), Matthew Clarke (3550808) (author), Amy R. Fairchild (15110801) (author), Thomas S. Jacques (15117937) (author), Richard G. Grundy (15018659) (author), Lisa Howell (15121538) (author), Susan Picton (3813571) (author), Jenny Adamski (11420832) (author), Shaun Wilson (5013728) (author), Juliet C. Gray (15121541) (author), Bassel Zebian (5986940) (author), Lynley V. Marshall (15110912) (author), Fernando Carceller (14945229) (author), Jacques Grill (15015216) (author), Maria Vinci (15121544) (author), Simon P. Robinson (14934318) (author), Michael Hubank (15104113) (author), Darren Hargrave (15016889) (author), Chris Jones (25458) (author)
Publicado em:	2025
Assuntos:	Cancer Therapeutic Research and Development CNS Cancers Gliomas, Glioblastomas Pediatric Cancers Small Molecule Agents Kinase inhibitors Translational Research
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