FLASHQuant: A Fast Algorithm for Proteoform Quantification in Top-Down Proteomics

FLASHQuant: A Fast Algorithm for Proteoform Quantification in Top-Down Proteomics

Accurate quantification of individual proteoforms is a crucial step in identifying proteome-wide alterations in different biological conditions. Intact proteoforms have been analyzed predominantly by liquid chromatography–mass spectrometry (LC-MS)-based top-down proteomics (TDP) and quantified prima...

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Bibliographic Details
Main Author: Jihyung Kim (7243529) (author)
Other Authors: Kyowon Jeong (6273380) (author), Philipp T. Kaulich (6408092) (author), Konrad Winkels (10661697) (author), Andreas Tholey (556130) (author), Oliver Kohlbacher (11422) (author)
Published: 2024
Subjects:
Biochemistry
Medicine
Sociology
Plant Biology
Space Science
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Information Systems not elsewhere classified
perform highly accurate
overlapping signals deriving
https :// openms
different biological conditions
complex signal structures
benchmark tests performed
additional costly labeling
quantifying coeluting proteoforms
minutes per lc
level lfq analysis
flashquant /, accompanied
proteomics accurate quantification
intact proteoforms
individual proteoforms
reproducible quantification
quantification accuracy
proteoform quantification
free quantification
wide alterations
source software
short runtimes
quantified primarily
publicly available
multiple lc
ms runs
ms run
introduce flashquant
independent open
frequent coelution
fast algorithm
crucial step
automatically resolving
analyzed predominantly
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