Disruption of organoid integrity and impaired forskolin response in PCOs infected with EBOV or MARV at high MOI.

<p>(A) At day 35 of differentiation, organoids were treated with forskolin at concentrations of 5, 10, and 20 µM (dissolved in DMSO) and imaged at 0 hours (top), 24 hours (middle), and 48 hours (bottom) to assess forskolin-induced swelling. Images were acquired using a Keyence BZ-X710 fluoresc...

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Bibliographic Details
Main Author:	Elizabeth Y. Flores (22676699) (author)
Other Authors:	Adam J. Hume (6107039) (author), Judith Olejnik (367849) (author), Aditya Mithal (22676702) (author), Andrew D’Amico (2248762) (author), MengWei Yang (22676705) (author), Pushpinder Bawa (733756) (author), Feiya Wang (21075016) (author), Aoife K. O’Connell (15462382) (author), Anna Tseng (20843165) (author), Nicholas A. Crossland (5500244) (author), Gustavo Mostoslavsky (110612) (author), Elke Mühlberger (45516) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Physiology Biotechnology Immunology Cancer Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified xlink "> gastrointestinal support viral replication providing mechanistic insight induced secretory diarrhea colonic epithelial responses model ebola virus mediated ion transport human gi pathology ion transport severe diarrhea human ipsc stimulated genes specific induction powerful system pathogen interactions marburg virus junctional disruption including apical filovirus disease filoviral disease dissect host delayed virus colonic organoids central contributor
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Disruption of organoid integrity and impaired forskolin response in PCOs infected with EBOV or MARV at high MOI.

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