Total Synthesis of the <i>Melodinus</i> Alkaloid (±)-Melohemsine K

Total Synthesis of the <i>Melodinus</i> Alkaloid (±)-Melohemsine K

The first total synthesis of the novel <i>Melodinus</i> alkaloid melohemsine K is described in five steps from known precursors. The key reaction of the synthesis is a tandem enamine formation/retro-aza-Michael reaction/Diels–Alder cycloaddition/intramolecular lactamization reaction casc...

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Bibliographic Details
Main Author: Shanhao Lin (6159902) (author)
Other Authors: Hao Jing (1426678) (author), Jinbo Duan (15064243) (author), Jing Fang (170284) (author), Gaoyuan Zhao (1332978) (author), Xingang Xie (1332975) (author), Huilin Li (795365) (author), Xuegong She (1332972) (author)
Published: 2025
Subjects:
Biochemistry
Cell Biology
Genetics
Molecular Biology
Sociology
Marine Biology
Infectious Diseases
Chemical Sciences not elsewhere classified
tandem enamine formation
alkaloid melohemsine k
first total synthesis
total synthesis
synthesis provided
michael reaction
melodinus </
known precursors
key reaction
general approach
fused azepine
five steps
aldehyde precursors
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