Total Synthesis of the <i>Melodinus</i> Alkaloid (±)-Melohemsine K

The first total synthesis of the novel <i>Melodinus</i> alkaloid melohemsine K is described in five steps from known precursors. The key reaction of the synthesis is a tandem enamine formation/retro-aza-Michael reaction/Diels–Alder cycloaddition/intramolecular lactamization reaction casc...

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Bibliographic Details
Main Author:	Shanhao Lin (6159902) (author)
Other Authors:	Hao Jing (1426678) (author), Jinbo Duan (15064243) (author), Jing Fang (170284) (author), Gaoyuan Zhao (1332978) (author), Xingang Xie (1332975) (author), Huilin Li (795365) (author), Xuegong She (1332972) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Genetics Molecular Biology Sociology Marine Biology Infectious Diseases Chemical Sciences not elsewhere classified tandem enamine formation alkaloid melohemsine k first total synthesis total synthesis synthesis provided michael reaction melodinus </ known precursors key reaction general approach fused azepine five steps aldehyde precursors
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Total Synthesis of the <i>Melodinus</i> Alkaloid (±)-Melohemsine K

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