Model describing how daily rhythmic O-GlcNAc proteome integrates environmental and metabolic signals to regulate transcriptomic and physiological rhythms.

<p>Environmental cues signaling through the molecular clock and metabolic cues from feeding–fasting cycles regulate daily rhythms in the O-GlcNAc proteome. Rhythmic O-GlcNAcylation can directly shape daily rhythmicity in transcriptome and physiology. In addition, rhythmic O-GlcNAcylation can a...

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Bibliografski detalji
Glavni autor:	Xianhui Liu (6281333) (author)
Daljnji autori:	Yao D. Cai (12716144) (author), Chunyan Hou (467106) (author), Xu Liu (276996) (author), Youcheng Luo (22311795) (author), Aron Judd P. Mendiola (22311798) (author), Xuehan Xu (7053587) (author), Yige Luo (12993279) (author), Haiyan Zheng (776635) (author), Caifeng Zhao (6551) (author), Ching-Hsuan Chen (10891567) (author), Yong Zhang (5893) (author), Yang K. Xiang (8614706) (author), Junfeng Ma (1413598) (author), Joanna C. Chiu (7553672) (author)
Izdano:	2025
Teme:	Biochemistry Cell Biology Genetics Molecular Biology Physiology Cancer Inorganic Chemistry Mental Health Computational Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified observe daily oscillation enriched among rhythmically metabolic signals generated daily nuclear protein supports temporal differences sensitive signaling pathways feeding &# 8211 several proteins harboring mediating metabolic regulation liver circadian clock global nuclear protein metabolic regulation nuclear proteins sensitive post restricted feeding proteins involved glcnacylated proteins night differences xlink "> whereas global using label translational modification transcriptional output shed light previous studies highly responsive hepatic transcriptome glcnac sites glcnac proteomics glcnac analysis gene expression free global food intake fasting rhythm deleterious effects
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Model describing how daily rhythmic O-GlcNAc proteome integrates environmental and metabolic signals to regulate transcriptomic and physiological rhythms.

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