Flowchart of the general algorithm for one trial.

<div><p>Adaptive designs for integrated phase I/II trials of drug combinations are increasingly utilized to speed up the drug development process and enhance drug efficacy, particularly in the realm of cancer therapy. The model-based Continual Reassessment Method (CRM) for dose-finding i...

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Bibliographic Details
Main Author:	Junying Wang (509009) (author)
Other Authors:	Song Wu (36667) (author), Jie Yang (121778) (author)
Published:	2025
Subjects:	Biophysics Medicine Genetics Pharmacology Biotechnology Cancer Science Policy Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified single trial based including maximum number guiding patient allocation evaluate operating characteristics create visual representations conducting extensive simulations applying partial orderings drug development process multiple trial parameters leverage accumulated data drug combinations using drug combinations based div >< p r </ p enhance drug efficacy ii adaptive design crm12comb </ b drug combinations specified parameters r package ii trials existing data adaptive designs crm design widely used wide range simulation studies prior distributions offering flexibility link functions increasingly utilized efficacy relationships cohort size cancer therapy binary outcomes bayesian framework
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Flowchart of the general algorithm for one trial.

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