Nilotinib treatment of Mtb-infected mice activates lysosome functions of lung myeloid subsets and reduces lung bacterial burdens.

<p>(A) Experimental protocol for treatment of Mtb-infected C57BL/6 mice. Mice infected with Mtb H37Rv-ZsGreen were treated with vehicle or nilotinib (20 mg/kg/day) intraperitoneally, 5 days/week, for a total of 15 doses beginning at 7 dpi and ending at 27 dpi. At 28 dpi, mice were euthanized,...

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Bibliographic Details
Main Author:	Weihao Zheng (767955) (author)
Other Authors:	I-Chang Chang (18501468) (author), Jason Limberis (8396535) (author), Jonathan M. Budzik (18501471) (author), Beth Shoshana Zha (18501474) (author), Zachary Howard (18501477) (author), Lucas Chen (563210) (author), Joel D. Ernst (7392614) (author)
Published:	2024
Subjects:	Medicine Microbiology Cell Biology Genetics Molecular Biology Immunology Developmental Biology Cancer Infectious Diseases Biological Sciences not elsewhere classified mycobacterium tuberculosis </ less nuclear tfeb functional studies revealed 1 secretion system highly permissive subset less lysosome content enhances lysosome functions drive lysosome deficiency lo </ sup hi </ sup permissive lung cells derived lung cells derived cells harbor poor lung cells targeting lysosome biogenesis mtb exploits lysosome permissive cells derived cells lysosome biogenesis lysosome pathway specific mtb results suggest proteolytic activity promotes recruitment potential host poor monocyte mtb infection mtb esx live mtb improving control directed therapy chronic infection cell responses ), neutrophils
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Nilotinib treatment of Mtb-infected mice activates lysosome functions of lung myeloid subsets and reduces lung bacterial burdens.

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