AUY922 represses HIV-1 reactivation in latently infected Jurkat cells.

<p>Latently infected Jurkat cells were stimulated with (A) anti-CD3/CD28 Abs [1μg/ml/2μg/ml], (B) PMA [0.9ng/ml], (C) PHA [0.27μg/ml], (D) ionomycin [1 μg/ml], (E) TNF-α [1.5 ng/ml], (F) FOXO-1 inh [200 nM], (G) TLR7 agonist [5μg ml] (H) TLR8 agonist [5μg/ml], or DMSO to induce HIV-1 reactivat...

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Bibliographic Details
Main Author:	Somaya Noorsaeed (20978766) (author)
Other Authors:	Nawal AlBurtamani (20978769) (author), Ahmed Rokan (20978772) (author), Ariberto Fassati (151654) (author)
Published:	2025
Subjects:	Biophysics Medicine Microbiology Cell Biology Molecular Biology Pharmacology Immunology Infectious Diseases Virology Biological Sciences not elsewhere classified therapy interruption results na &# 239 homozygous &# 916 1 gene expression multiple pathways need latently infected cells hsp90 abrogated activation hsp90 regulates hiv 1 reactivation mediated results indicate pharmacological reactivation mediated clearance &# 8221 &# 8220 activation status activation state infected cd4 hsp90 promotes hsp90 might hsp90 inhibition 1 inhibitor 1 globally xlink "> viral rebound therefore lifelong regulate hiv proper folding primary cells phorbol esters master regulator jurkat model hypothesis using chemical inhibition chaperone regulator ccr5 donors broadly applicable although knowledge
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AUY922 represses HIV-1 reactivation in latently infected Jurkat cells.

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