Spermidine Prevents Polarity Loss of Absorptive Enterocytes in Jejunum of Lipopolysaccharide-Challenged Mice via 4D-DIA Proteomics Analysis

Identifying effective compounds to restore the polarity of absorptive enterocytes (AEs) holds promise for mitigating the severity and duration of small intestinal disorders. Spermidine (SPD) is a natural polyamine; whether it can repair inflammation-induced loss of AE polarity remains unclear. In th...

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Bibliographic Details
Main Author:	Pengchao Zheng (22674589) (author)
Other Authors:	Shiyi Tian (5868122) (author), Zhen Chen (129176) (author), Yi Zhang (9093) (author), Keyi Jiang (3603341) (author), Ziyang Zha (22674592) (author), Jue Wang (58890) (author), Baosheng Liu (3042366) (author)
Published:	2025
Subjects:	Biochemistry Physiology Immunology Astronomical and Space Sciences not elsewhere classified Chemical Sciences not elsewhere classified small intestinal disorders proteomic analysis revealed apical slc transporters 2 cell model specific immune responses spd supplementation enhanced spd effectively alleviates spd attenuated mucosal inflammatory responses treated mice significantly downregulating results demonstrated proteins involved protein groups pards ), natural polyamine inflammatory effect induced loss independent acquisition holds promise hdac4 signaling findings indicate epithelial morphology cytoskeletal proteins crypt ratio challenged mice antioxidant capacity absorptive enterocytes 4d data
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Spermidine Prevents Polarity Loss of Absorptive Enterocytes in Jejunum of Lipopolysaccharide-Challenged Mice via 4D-DIA Proteomics Analysis

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