Discovery of Selective PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects by Targeting the Metal Pocket

Discovery of Selective PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects by Targeting the Metal Pocket

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with no ideal drugs. Our previous research demonstrated that phosphodiesterase 1 (PDE1) could be a promising target for the treatment of IPF. However, only a few selective PDE1 inhibitors are available, and the mechanism of recognition betw...

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Bibliographic Details
Main Author: Mei-Yan Jiang (5725319) (author)
Other Authors: Chen Zhang (66790) (author), Qing-Hua Huang (4710582) (author), Ling-Ling Feng (5175737) (author), Yi-Yi Yang (12797319) (author), Qian Zhou (125859) (author), Hai-Bin Luo (225984) (author), Yinuo Wu (1348221) (author)
Published: 2024
Subjects:
Biochemistry
Medicine
Molecular Biology
Pharmacology
Cancer
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Information Systems not elsewhere classified
previous research demonstrated
molecular docking revealed
forming halogen bonds
fatal lung disease
pulmonary fibrosis effects
50 </ sub
3f </ b
selective pde1 inhibitors
fibrotic effects
study carried
rational design
promising target
phosphodiesterase 1
pde1 protein
pde1 inhibitors
pde1 inhibition
novel strategy
moderate selectivity
metal pocket
lead compound
ideal drugs
fully understood
dihydropyrimidine hit
11 nm
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