Functional impact of FP modifications.

Dose-response curves of A) PGF2α and C) cloprostenol-induced activation of the Rho signaling pathway via FP. WT and mutant FP receptors were transiently expressed in HEK293T cells along with the RhoA BRET biosensor to measure G protein response foll...

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Autor Principal:	Marine Salze (8467257) (author)
Outros autores:	Sébastien Chrétien (21743678) (author), Tegvir S. Boora (21743681) (author), Madalina Macovei (21743684) (author), Eric Barbeau (21743687) (author), Véronique Blais (7388231) (author), Stéphane A. Laporte (7654517) (author), Martin Audet (192220) (author)
Publicado:	2025
Subjects:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Biotechnology Immunology Developmental Biology Infectious Diseases Computational Biology Chemical Sciences not elsewhere classified vascular tone regulation third intracellular loop mediates signaling events div >< p protein engineering effort icl3 ), n single particle cryo pursuing alternative strategies orthosteric binding site bioactive lipid derived fp protein sequence g protein fp ), vitro </ threefold improvement structural biology ray crystallography purified fp prostaglandin f point mutations pathophysiological processes new x many physiological ligand complexes fully understand electron microscopy different efficacies dependent plasticity atomic level arachidonic acid 5 mg
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Functional impact of FP modifications.

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