Differential impact of EBOV and MARV on cAMP-mediated function in human gut organoids reveals region-specific loss of forskolin-induced swelling in HCOs.

<p>(A) iPSC-derived HIOs were infected with EBOV, EBOV-ZsGreen, or MARV at an MOI of 10 on day 35 of differentiation. At 1 dpi, HIOs were treated with 5 µM forskolin dissolved in DMSO or treated with DMSO and imaged immediately prior to treatment (0 hours, 1 dpi), and then at 24 hours (2 dpi),...

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1. Verfasser:	Elizabeth Y. Flores (22676699) (author)
Weitere Verfasser:	Adam J. Hume (6107039) (author), Judith Olejnik (367849) (author), Aditya Mithal (22676702) (author), Andrew D’Amico (2248762) (author), MengWei Yang (22676705) (author), Pushpinder Bawa (733756) (author), Feiya Wang (21075016) (author), Aoife K. O’Connell (15462382) (author), Anna Tseng (20843165) (author), Nicholas A. Crossland (5500244) (author), Gustavo Mostoslavsky (110612) (author), Elke Mühlberger (45516) (author)
Veröffentlicht:	2025
Schlagworte:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Physiology Biotechnology Immunology Cancer Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified xlink "> gastrointestinal support viral replication providing mechanistic insight induced secretory diarrhea colonic epithelial responses model ebola virus mediated ion transport human gi pathology ion transport severe diarrhea human ipsc stimulated genes specific induction powerful system pathogen interactions marburg virus junctional disruption including apical filovirus disease filoviral disease dissect host delayed virus colonic organoids central contributor
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Differential impact of EBOV and MARV on cAMP-mediated function in human gut organoids reveals region-specific loss of forskolin-induced swelling in HCOs.

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