FVIII-KO hemarthrosis model.

FVIII-KO hemarthrosis model.

<p>Hemarthrosis was induced in FVIII-KO mice by sub-patellar needle puncture. Saline, rhFVIII, or mFcFVIII prophylaxis was given 2 h before and 6 h after injury (n = 3 to 5 per group). The extent of intra/peri‐articular bleeding was determined by hematocrit measurement on day 2 after injury. S...

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Bibliographic Details
Main Author: Bilgimol Chumappumkal Joseph (21387752) (author)
Other Authors: Thomas C. Whisenant (15124111) (author), Esther J. Cooke (21387755) (author), Jenny Y. Zhou (6951371) (author), Nicca Falah (21387758) (author), Juan Andres De-Pablo Moreno (21387761) (author), Annette von Drygalski (615964) (author)
Published: 2025
Subjects:
Biochemistry
Genetics
Molecular Biology
Physiology
Immunology
Biological Sciences not elsewhere classified
synovial gene expression
observations provide proof
may modulate inflammation
macrophage profiling indicated
differential gene expression
ko mice resulted
synovial vascular remodeling
also distinct differences
deficient mice treated
joint bleed control
immune system pathways
hemophilic synovium via
d3 ), mfcfviii
fc fusion protein
target effects related
deficient mice
tissue remodeling
temporal differences
protein processing
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target effects
small proportion
rnaseq data
rna extraction
reactome ).
patellar puncture
mfcfviii treatments
life extension
inflammatory regulation
immunoglobulin used
immune stimulation
following groups
exhibiting overlap
deserving exploration
cartilage health
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