Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution

Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution

Various agents, including drugs as well as nonmolecular stimuli, induce alterations in the physicochemical properties of proteins in cell lysates, living cells, and organisms. These alterations can be probed by applying a stability- and solubility-modifying factor, such as elevated temperature, to a...

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Bibliographic Details
Main Author: Massimiliano Gaetani (241969) (author)
Other Authors: Pierre Sabatier (2927019) (author), Amir A. Saei (7495229) (author), Christian M. Beusch (7495232) (author), Zhe Yang (8942) (author), Susanna L. LundstroĢˆm (7495235) (author), Roman A. Zubarev (493595) (author)
Published: 2019
Subjects:
Biophysics
Biochemistry
Medicine
Genetics
Pharmacology
Biotechnology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
drug concentrations
analysis throughput
agent
Target Deconvolution
physicochemical properties
chemical biology
High-Throughput Proteomics Assay
2 orders
cell lysates
material decreases
drug concentration
solubility-modifying factor
PISA approach
Proteome Integral Solubility Alteration
protein solubility data
nonmolecular stimuli
alteration
assay increases
drug development
factor variation points
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